I've been running road tubeless for a while and it is a near perfect solution for my punctures. There was a lot of thinking behind going to road tubeless for me.
I'd just moved house and my commute was now a long stretch of the Hume Hwy on my only road bike at the time, 3 days a week. Two rides in and I had destroyed a pair of Conti GP4000S tyres. Obviously they weren't the best tyres for the job. I put on some Maxxis Re-Fuses and got the punctures down to about one a week running 130psi. Anything lower and punctures became more frequent. Sometimes two in a day, but always at least one a week. The ride wasn't as nice now either. In went some tyre liners. Punctures were now down to about one a fortnight-month. Feel on the road was terrible. Tubes were harder to replace with the liners in and the truck belt tyre wire that was causing the punctures was harder to remove as well. Tweezers had become a mandatory part of my ride toolkit.
Then I went road tubeless with 6700 Ultegra wheels and Hutchinson Fusion 3 tyres. Road feel was back at the Conti level but I was still averaging about 1 puncture per month. The problem now was that the punctures caused by the wire were sealed well enough to finish the ride each time and I could patch the tyre when I got home, but twice I managed to inflict large cuts (5-10mm) to the tyres that the sealant couldn't fully seal. Chucking a tube in on the side of the road isn't a problem.
I've since found three solutions. 1. Change the route! I have to go a slightly longer and much hillier route, but I haven't had a puncture on the crappy rural roads. 2. Change the tyres to IRC Formula Pro with X-Guard and no more punctures. 3. I bought a cross bike and fitted Schwalbe Marathon Plus tyres. Road feel is crap and I've managed to puncture once with the truck tyre belt wire. These are harder to fit a tube into than the tubeless tyres.
So for me, road tubeless is brilliant. A nice set of RT specific wheels (Dura Ace C24TL) with the right tyres cannot be beat. 90-100psi for a smoother ride, no increase in rolling resistance that I can feel, almost no punctures that require me to stop and fit a tube. Sealant works and isn't messy. The only negative I can find is that until Easton releases their deep profile RT wheel, there hasn't been one readily available. The Corima wheelset always seemed a bit pricey if available.
I can see people having problems with ghetto set ups due to the higher pressures than on mtbs. But with a proper road tubeless set up, people who make a mess with sealant or cannot fit a tube without issues just need more practice.
