Each person will have their own ideas about what is the best way to go.
Tubeless rim/tubeless tyre will be the best bet for a failsafe setup.
In saying that.....
I have run tubeless wheels(crossmax SX) with UST tyres(Hutchinson Barracuda),and burped the tyre,leading to a pinched sidewall due to lower than normal air pressure.Same wheels with Eskar 2bliss tyres, which I found to be too thin in the sidewall, which got lots of nicks and small tears in the sidewall.
Mavic 317 done ghetto, with homemade solution,fitted with non ust larsens, and they were great.
Mavic 723, ghetto again with 2.7 minions. Worked well, until I didnt ride it for a couple of weeks, and a mysterious leak appeared through the spoke nipples. They were done with the "tyre tube cut down to form the innerliner" method with tape over the spoke holes.
TWE wheels ,done ghetto with non UST larsen TT's worked well through a few endurance races, never had a problem...
Lighter tyres MAY suit a lighter,or should I say,smoother rider than someone who "plows" through the rough. Some light tyres flex too much through the sidewall, and can feel "wallowy". They may conversely, give a little bit more comfort due to the sidewall acting like a little bit more suspension. So, different riders riding the same tyre may feel totally opposite to each other, due to their riding style.
Pity they are so expensive !!
Its hard to test tyres, as you dont really want to waste money on trial and error. That could be why some riders stay with the same type of tyre for years, as they think they are "on a good thing"with their tyre of choice,even if new compounds, and technologies are discovered..
Thats why this thread is so important !!!! It helps all riders make decisions..... or confuses the hell out of them !!