Saw a massive dude riding xc at Ourimbah a few years back. I'd have estimated his weight to be in the category you're talking about (based on friends that are generally considered fairly big). This must have been the only time he had left the gym in the previous decade. His arms were like my legs, he had plenty of height, and 2 barrels for a chest. Just monstrous. He was tearing up a climb on an Original giant faith. I'd owned one of them and they were anyway bike. Perhaps not the answer to your question, but he had adapted to suit his size.