It's a scale. It doesn't matter where you play it. I use every position, just depends where I want to be.
That said, with my slightly out of proportion hands and all the Paul Gilbert stuff I like to think I can play, the whole tone steps feel normal. Hell, I'm breaking it up into bigger intervals like 1st, 3rd, 5th, 7th, 9th, etc. To mix it up a bit and give me more options with where I want to take it. It's also a bit more of a workout to think in intervals rather than sequential steps in a scale.
On other notes, I've got something to offend Joy, a particular song which is my everest, and a 'band' that has forced me to take a different, fresh look at playing.
Which is fantastic. I've written more stuff that I actually like in the last month than the last year. In terms of the kind of alt/indie/pop/something? genre which holds a place in my heart.
EDIT: Valve amps are bastards if you aren't patient with some knowledge. I was reading for hours before I dove into mine.
If you build one, start with something like a Champ circuit. Or even a low gain one from ax84.
Or, this one
http://www.evatco.com.au/sonic.htm
They are a very linear, fundamentally simple thing to build. Start low gain, as the higher the gain, the more important EVERYTHING becomes. Where high sensitivity wires are place relative to others, grounding technique, elevating heaters, types of components, etc. etc.
Low gain, not so bad, there's room to wiggle. Just be methodical and patient, and there's not a lot that can go seriously wrong. The hardest bit will be wiring something neatly. And make sure the filter caps are the correct orientation. Other than that, troubleshooting is time consuming, but simple. There are only so many things that can happen, as these things are, at their core, such a simple concept.
And Zappa leaves my jaw on the ground every time. Dweezil and Frank. Wow?